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metadata.dc.type: Artigo de Periódico
Title: Effect of 1% sodium alendronate in the non-surgical treatment of periodontal intraosseous defects: a 6-month clinical trial
Authors: Dutra, Bernardo Carvalho
Oliveira, Alcione Maria Soares Dutra
Oliveira, Peterson Antônio Dutra
Manzi, Flavio Ricardo
Cortelli, Sheila Cavalca
Cota, Luís Otávio de Miranda
Costa, Fernando Oliveira
Abstract: Abstract Background and objectives Few studies have evaluated the effect of the topical application of sodium alendronate (ALN) on the treatment of intrabuccal bone defects, especially those caused by periodontitis. This 6-month randomized placebo controlled clinical trial aimed at evaluating the effect of non-surgical periodontal treatment associated with the use of 1% ALN, through clinical evaluations and cone-beam computed tomography (CBCT). Material and Methods Twenty individuals with chronic periodontitis underwent periodontal examination at the baseline as well as 3 and 6 months after periodontal treatment, registering clinical attachment level (CAL), periodontal probing depth (PPD), and bleeding on probing (BOP) as the clinical outcomes. After manual scaling and root planing, 40 bilateral sites with interproximal vertical bone defects were randomly treated with either 1% ALN gel or a placebo. Bone defects were evaluated through CBCT at the baseline and 6 months post-treatment. The clinical and CBCT parameters were compared using the Wilcoxon and Friedman tests (p<0.05). Results Although ALN produced a greater CAL gain when compared to the placebo at 6 months post-treatment (p=0.021), both treatments produced similar effects on the PPD, BOP, and bone height. Significant differences in bone fill were observed only in patients of the ALN group (4.5 to 3.8 mm; p=0.003) at 6 months post-treatment. Conclusions Topical application of 1% ALN might be a beneficial adjuvant to non-surgical periodontal therapy.
metadata.dc.language: Inglês
Publisher: Faculdade De Odontologia De Bauru - USP
metadata.dc.rights: Acesso Aberto
metadata.dc.identifier.doi: 10.1590/1678-7757-2016-0252
Issue Date: 2017
Appears in Collections:Artigos de Periódicos

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