Please use this identifier to cite or link to this item: http://repositorio.unitau.br/jspui/handle/20.500.11874/2046
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dc.contributor.authorLee E.J.pt_BR
dc.contributor.authorJang S.I.pt_BR
dc.contributor.authorPallos, Déborapt_BR
dc.contributor.authorKather J.pt_BR
dc.contributor.authorHart, Thomas Charlespt_BR
dc.date.accessioned2019-09-12T16:32:46Z-
dc.date.available2019-09-12T16:32:46Z-
dc.date.issued2006-
dc.citation.volume85pt_BR
dc.citation.issue11pt_BR
dc.citation.spage1050-
dc.citation.epage1055-
dc.identifier.doi10.1177/154405910608501115pt_BR
dc.identifier.issn220345-
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-33750684698&doi=10.1177%2f154405910608501115&partnerID=40&md5=a372e8864e8208e98621481fe607d612-
dc.identifier.urihttp://repositorio.unitau.br/jspui/handle/20.500.11874/2046-
dc.description.abstractAlthough non-syndromic hereditary gingival fibromatosis (HGF) is genetically heterogeneous, etiologic mutations have been identified only in the Son of Sevenless-1 gene (SOS1). To test evidence of increased cell proliferation, we studied histological, morphological, and proliferation characteristics in monolayer and three-dimensional cultures of fibroblasts with the SOS1 g.126,142-126,143insC mutation. Histological assessment of HGF gingiva indicated increased numbers of fibroblasts (30%) and increased collagen (10%). Cell proliferation studies demonstrated increased growth rates and 5-bromo-2-deoxyuridine incorporation for HGF fibroblasts. Flow cytometry showed greater proportions of HGF fibroblasts in the G2/M phase. Attachment of HGF fibroblasts to different extracellular matrix surfaces demonstrated increased formation of protrusions with lamellipodia. HGF fibroblasts in three-dimensional culture showed greater cell proliferation, higher cell density, and alteration of surrounding collagen matrix. These findings revealed that increased fibroblast numbers and collagen matrix changes are associated with mutation of the SOS1 gene in vitro and in vivo.en
dc.description.provenanceMade available in DSpace on 2019-09-12T16:32:46Z (GMT). No. of bitstreams: 0 Previous issue date: 2006en
dc.languageInglêspt_BR
dc.relation.ispartofJournal of Dental Research-
dc.rightsAcesso Restritopt_BR
dc.sourceScopuspt_BR
dc.subject.otherCollagenen
dc.subject.otherFibroblasten
dc.subject.otherHereditary gingival fibromatosisen
dc.subject.otherSon of Sevenless-1en
dc.subject.othercollagenen
dc.subject.otherSOS proteinen
dc.subject.otheradulten
dc.subject.otherarticleen
dc.subject.othercase control studyen
dc.subject.othercell adhesionen
dc.subject.othercell cycle G2 phaseen
dc.subject.othercell cycle S phaseen
dc.subject.othercell proliferationen
dc.subject.otherchemistryen
dc.subject.othercytologyen
dc.subject.otherextracellular matrixen
dc.subject.otherfibroblasten
dc.subject.otherframeshift mutationen
dc.subject.othergeneticsen
dc.subject.othergingivaen
dc.subject.othergingiva fibromatosisen
dc.subject.otherhumanen
dc.subject.otherpathologyen
dc.subject.otherAdulten
dc.subject.otherCase-Control Studiesen
dc.subject.otherCell Adhesionen
dc.subject.otherCell Proliferationen
dc.subject.otherCollagenen
dc.subject.otherExtracellular Matrixen
dc.subject.otherFibroblastsen
dc.subject.otherFibromatosis, Gingivalen
dc.subject.otherFrameshift Mutationen
dc.subject.otherG2 Phaseen
dc.subject.otherGingivaen
dc.subject.otherHumansen
dc.subject.otherS Phaseen
dc.subject.otherSOS1 Proteinen
dc.titleCharacterization of fibroblasts with Son of Sevenless-1 mutationen
dc.typeArtigo de Periódicopt_BR
dc.description.affiliationLee, E.J., Human Craniofacial Genetics Section, NIDCR, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, United States-
dc.description.affiliationJang, S.I., Human Craniofacial Genetics Section, NIDCR, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, United States-
dc.description.affiliationPallos, D., Department of Periodontology, University of Taubate, Brazil-
dc.description.affiliationKather, J., Department of Periodontology, University of Taubate, Brazil-
dc.description.affiliationHart, T.C., Human Craniofacial Genetics Section, NIDCR, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, United States-
dc.identifier.scopus2-s2.0-33750684698-
dc.contributor.scopus7406969193pt_BR
dc.contributor.scopus7402219139pt_BR
dc.contributor.scopus6506802228pt_BR
dc.contributor.scopus23489158400pt_BR
dc.contributor.scopus7102730199pt_BR
Appears in Collections:Artigos de Periódicos

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