Please use this identifier to cite or link to this item: http://repositorio.unitau.br/jspui/handle/20.500.11874/2634
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dc.contributor.authorCallegari, Desire Carlospt_BR
dc.contributor.authorCorrea, Joao Antoniopt_BR
dc.contributor.authorPires, Oscar Césarpt_BR
dc.contributor.authorCorrea Braga, Renan Batistapt_BR
dc.contributor.authorMarques Gimbo, Ana Flaviapt_BR
dc.contributor.authorde Souza, Adriana Aparecidapt_BR
dc.contributor.authorRovani Pires, Marta Helenapt_BR
dc.contributor.authorConstantino, Eltonpt_BR
dc.contributor.authorPosso, Irimar de Paulapt_BR
dc.date.accessioned2019-09-12T16:53:34Z-
dc.date.available2019-09-12T16:53:34Z-
dc.date.issued2015-
dc.citation.volume65pt_BR
dc.citation.issue2pt_BR
dc.citation.spage111-
dc.citation.epage116-
dc.identifier.doi10.1016/j.bjan.2013.09.012pt_BR
dc.identifier.issn0034-7094-
dc.identifier.issn1806-907X-
dc.identifier.urihttp://repositorio.unitau.br/jspui/handle/20.500.11874/2634-
dc.description.abstractBackground and objectives: Painful phenomenon is one of the most important and complex experiences. Phentolamine is a non-selective alpha-adrenergic antagonist. The objective of this study was to compare the effect of increasing doses of phentolamine into subarachnoid space in rats in the modulation of painful phenomenon. Methods: 84 male Wistar rats were divided into formalin and plantar incision groups, subdivided into six subgroups (n = 7). Control group (CG) received only saline (10 mu L); active subgroups received phentolamine 10 mu mg (GF10), 20 mg (GF20), 30 mg (GF30), 40 mg (GF40), and 50g (GF50). In formalin group, pain was induced by injection of 50 mu L of 2% formalin in dorsal region of right posterior paw. In plantar incision group, pain was induced by plantar incision and evaluated using Von Frey filaments. Induction and maintenance of anesthesia were performed with 3% halothane for catheter placement into subarachnoid space and plantar incision. Statistical analysis was performed using the JMP program from SAS with 5% significance level. Results: Phentolamine at doses of 20 and 30 g increased the algesic response in the intermediate phase of the formalin test. In plantar incision test, it had hyperalgic effect on first, third, fifth, and seventh days at a dose of 10 g and on first, third, and fifth days at a dose of 20g and on fifth day at a dose of 30g. Conclusion: Subarachnoid administration of phentotamine showed hyperalgesic effect, possibly due to the involvement of different subclasses of alpha-adrenergic receptors in modulating pain pathways. (C) 2014 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. All rights reserved.en
dc.description.provenanceMade available in DSpace on 2019-09-12T16:53:34Z (GMT). No. of bitstreams: 0 Previous issue date: 2015en
dc.languagePortuguêspt_BR
dc.publisherElsevier Science Inc-
dc.publisher.countryEstados Unidospt_BR
dc.relation.ispartofRevista Brasileira de Anestesiologia-
dc.rightsEm verificaçãopt_BR
dc.sourceWeb of Sciencept_BR
dc.subject.otherMiceen
dc.subject.otherPhentolamineen
dc.subject.otherPainen
dc.subject.otherFormalin Testen
dc.subject.otherVon Freyen
dc.subject.otherPainen
dc.subject.other5-Hydroxytryptamineen
dc.subject.otherBehavioren
dc.titleHyperalgesic effect of subarachnoid administration of phentolamine in miceen
dc.typeArtigo de Periódicopt_BR
dc.identifier.wosWOS:000352509700005-
dc.description.affiliation[Callegari, Desire Carlos; Correa, Joao Antonio] Fac Med ABC FMABC, Santo Andre, SP, Brazil-
dc.description.affiliation[Pires, Oscar Cesar; Constantino, Elton; Posso, Irimar de Paula] Universidade de Taubaté (Unitau) Unitau-
dc.description.affiliation[Correa Braga, Renan Batista] Universidade de Taubaté (Unitau) Unitau, Curso Med-
dc.description.affiliation[Marques Gimbo, Ana Flavia] Universidade de Taubaté (Unitau) Unitau, Curso Enfermagem-
dc.description.affiliation[de Souza, Adriana Aparecida] Universidade de Taubaté (Unitau) Unitau, Curso Biol-
dc.description.affiliation[Rovani Pires, Marta Helena] Fac Med Petropolis, Curso Med, Petropolis, RJ, Brazil-
dc.subject.wosareaAnesthesiologyen
dc.subject.researchareaAnesthesiologyen
Appears in Collections:Artigos de Periódicos

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