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DC Field | Value | Language |
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dc.contributor.author | Amaral, Sergio Antonucci | pt_BR |
dc.contributor.author | Pereira, Thais Santos Fontes | pt_BR |
dc.contributor.author | Brito, Joao Artur Ricieri | pt_BR |
dc.contributor.author | Cortelli, Sheila Cavalca | pt_BR |
dc.contributor.author | Cortelli, José Roberto | pt_BR |
dc.contributor.author | Gomez, Ricardo Santigo | pt_BR |
dc.contributor.author | Costa, Fernando Oliveira | pt_BR |
dc.contributor.author | Cota, Luís Otávio de Miranda | pt_BR |
dc.date.accessioned | 2019-09-12T16:56:47Z | - |
dc.date.available | 2019-09-12T16:56:47Z | - |
dc.date.issued | 2019 | - |
dc.citation.volume | 25 | pt_BR |
dc.citation.issue | 2 | pt_BR |
dc.citation.spage | 561 | - |
dc.citation.epage | 568 | - |
dc.identifier.doi | 10.1111/odi.12994 | pt_BR |
dc.identifier.issn | 1354-523X | - |
dc.identifier.issn | 1601-0825 | - |
dc.identifier.uri | http://repositorio.unitau.br/jspui/handle/20.500.11874/2862 | - |
dc.description.abstract | Objectives MicroRNAs (miRNAs) may play an important role in inflammatory response. However, the involvement of miRNAs in the pathogenesis of periodontitis is unclear. The present study aimed to compare the miRNA expression profiles in individuals with chronic (CP) or aggressive (AP) periodontitis. Materials and methods Eighteen non-smoker individuals (CP = 9 and AP = 9) without any history of systemic diseases or previous periodontal therapies were selected at the Clinics of Periodontology from the Federal University of Minas Gerais. Gingival tissue samples were collected during the initial periodontal therapy. miRNAs were isolated, and expression patterns of 754 miRNAs were assessed with a quantitative miRNA PCR array. miRNAs expression profiles were compared between CP and AP groups. Results There were no differences observed in the miRNAs expression profiles between CP and AP (p > 0.05). According to the microarray analyses, the most expressed miRNAs in both groups were hsa-miR-1274b, hsa-let-7b-5p, hsa-miR-24-3p, hsa-miR-19b-3p, hsa-miR-720, hsa-miR-126-3p, hsa-miR-17-3p and hsa-miR-21-3p. Conclusion Findings suggested no differences in miRNAs expression profiles between chronic and aggressive forms of periodontitis. The overexpression of specific miRNAs could provide insights into the pathogenesis of both forms of the disease. | en |
dc.description.provenance | Made available in DSpace on 2019-09-12T16:56:47Z (GMT). No. of bitstreams: 0 Previous issue date: 2019 | en |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | pt_BR |
dc.language | Inglês | pt_BR |
dc.publisher | Wiley | - |
dc.publisher.country | Estados Unidos | pt_BR |
dc.relation.ispartof | Oral Diseases | - |
dc.rights | Em verificação | pt_BR |
dc.source | Web of Science | pt_BR |
dc.subject.other | Aggressive Periodontitis | en |
dc.subject.other | Chronic Periodontitis | en |
dc.subject.other | Mirna | en |
dc.subject.other | Pathogenesis | en |
dc.subject.other | Gingival Crevicular Fluid | en |
dc.subject.other | Microrna Expression | en |
dc.subject.other | Let-7 | en |
dc.subject.other | Classification | en |
dc.subject.other | Association | en |
dc.subject.other | Biogenesis | en |
dc.subject.other | Modulation | en |
dc.subject.other | Cancer | en |
dc.subject.other | Genes | en |
dc.title | Comparison of miRNA expression profiles in individuals with chronic or aggressive periodontitis | en |
dc.type | Artigo de Periódico | pt_BR |
dc.contributor.orcid | Gomez, Ricardo Santiago https://orcid.org/0000-0001-8770-8009 | pt_BR |
dc.contributor.orcid | Costa, Fernando https://orcid.org/0000-0002-7687-1238 | pt_BR |
dc.contributor.researcherid | Gomez, Ricardo Santiago/G-1976-2012 | pt_BR |
dc.identifier.wos | WOS:000458899300023 | - |
dc.description.affiliation | [Amaral, Sergio Antonucci; Fontes Pereira, Thais Santos; Ricieri Brito, Joao Artur; Gomez, Ricardo Santigo; Costa, Fernando Oliveira; Miranda Cota, Luis Otavio] Univ Fed Minas Gerais, Sch Dent, Dept Dent Clin Oral Pathol & Oral Surg, Belo Horizonte, MG, Brazil | - |
dc.description.affiliation | [Cortelli, Sheila Cavalca; Cortelli, Jose Roberto] Universidade de Taubaté (Unitau), Dept Dent, Periodont Res Div | - |
dc.subject.wosarea | Dentistry, Oral Surgery & Medicine | en |
dc.subject.researcharea | Dentistry, Oral Surgery & Medicine | en |
Appears in Collections: | Artigos de Periódicos |
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