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DC Field | Value | Language |
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dc.contributor.author | Ruenis, Ana Paula Del Bortolo | pt_BR |
dc.contributor.author | Franco, Gilson César Nobre | pt_BR |
dc.contributor.author | Baglie, Sinvaldo | pt_BR |
dc.contributor.author | Motta, Rogério Heládio Lopes | pt_BR |
dc.contributor.author | Simões, Roberta Pessoa Simões | pt_BR |
dc.contributor.author | Rosalen, Pedro Luiz | pt_BR |
dc.contributor.author | Franco, Luís Fernando Mercier | pt_BR |
dc.contributor.author | Moreno, Ricardo Alberto | pt_BR |
dc.contributor.author | Abib Junior, Eduardo | pt_BR |
dc.contributor.author | Groppo, Francisco Carlos | pt_BR |
dc.date.accessioned | 2019-09-12T16:57:15Z | - |
dc.date.available | 2019-09-12T16:57:15Z | - |
dc.date.issued | 2009 | - |
dc.citation.volume | 47 | pt_BR |
dc.citation.issue | 2 | pt_BR |
dc.citation.spage | 96 | - |
dc.citation.epage | 103 | - |
dc.identifier.issn | 0946-1965 | - |
dc.identifier.uri | http://repositorio.unitau.br/jspui/handle/20.500.11874/3178 | - |
dc.description.abstract | Objective: To assess the pharmacokinetics of clarithromycin (CLR) and its effects oil oral and nasal microbiota in healthy volunteers in an open, randomized, two-period crossover design. Methods: A single 500 mg oral dose of CLR (Group 1: Merck Group 2: Klaricid) was administered observing a 1-week interval between doses. Blood samples were collected from pre-dose to 24 h. plasmatic concentrations of CLR were quantified by the LC-MS-MS method. Saliva and nasal mucosa swabs were obtained previously and after 1.33, 2, 6 and 12 11 of drug administration. Pharmacokinetics and PK/PD (t>MIC, %t>MIC and AUC(0-24)/MIC ratio) parameters were estimated. The microogranism counts were obtained on different Culture media. Results: No statistically significant differences were observed between the two formulations (p>0.05) regarding the pharmacokinetic parameters. Total microorganisms, staphylococci and streptococci counts did not show statistical differences (p>0.05) between the two groups during each sampling time. Considering the microorganisms of each group, no statistically significant differences were found after drug administration, but all differed from pre-dose Counts (p<0.05). The observed t>MIC ranged from 14.45 h (+/- 1.69) to 1.19 h (+/- 2.17) considering MICs of 0.25 mu g/ml and 2.0 mu g/ml, respectively. There was no correlation between any t>MIC %t>MIC or AUC(0-24) and bacterial reduction (between 0- and 12-h periods), However, the profile or reduction Of Microorganisms in both saliva and nasal samples were compatible with high values of %t>MIC verified for both clarithromycin formulations. Conclusion: Both formulations of clarithromycin had similar pharmacokinetics and efficacy. | en |
dc.description.provenance | Made available in DSpace on 2019-09-12T16:57:15Z (GMT). No. of bitstreams: 0 Previous issue date: 2009 | en |
dc.description.sponsorship | Merck S.A Industrias Químicas | pt_BR |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | pt_BR |
dc.language | Inglês | pt_BR |
dc.publisher | Dustri-Verlag Dr Karl Feistle | - |
dc.publisher.country | Alemanha | pt_BR |
dc.relation.ispartof | International Journal of Clinical Pharmacology and Therapeutics | - |
dc.rights | Em verificação | pt_BR |
dc.source | Web of Science | pt_BR |
dc.subject.other | Clarithromycin | en |
dc.subject.other | Pk/Pd | en |
dc.subject.other | Staphylococci | en |
dc.subject.other | Streptococci | en |
dc.subject.other | A-56268 Te-031 | en |
dc.subject.other | Time-Kill | en |
dc.subject.other | In-Vitro | en |
dc.subject.other | Anaerobic-Bacteria | en |
dc.subject.other | Invitro Activity | en |
dc.subject.other | Agents | en |
dc.subject.other | Erythromycin | en |
dc.subject.other | Macrolide | en |
dc.subject.other | Pharmacodynamics | en |
dc.subject.other | Pharmacokinetics | en |
dc.title | A PK/PD approach on the effects of clarithromycin against oral and nasal microbiota of healthy volunteers | en |
dc.type | Artigo de Periódico | pt_BR |
dc.contributor.orcid | Rosalen, Pedro Luiz https://orcid.org/0000-0003-0812-4027 | pt_BR |
dc.contributor.orcid | Groppo, Francisco https://orcid.org/0000-0002-8513-773X | pt_BR |
dc.contributor.researcherid | Rosalen, Pedro Luiz/I-3718-2012 | pt_BR |
dc.contributor.researcherid | Groppo, Francisco/C-3516-2012 | pt_BR |
dc.contributor.researcherid | Franco, Gilson/F-9312-2012 | pt_BR |
dc.identifier.wos | WOS:000263620100004 | - |
dc.description.affiliation | [Ruenis, A. P. Del Bortolo; Simoes, R. P.; Rosalen, P. L.; Groppo, F. C.] State Univ Campinas UNICAMP, Piracicaba Dent Sch, BR-13414903 Piracicaba, SP, Brazil | - |
dc.description.affiliation | [Franco, G. C. Nobre] Universidade de Taubaté (Unitau) | - |
dc.description.affiliation | [Motta, R. H. Lopes] Sao Leopoldo Dent Sch, Dept Physiol Sci, Campinas, SP, Brazil | - |
dc.description.affiliation | [Franco, L. M.] Univ Metodista Piracicaba, Fac Hlth Sci, Piracicaba, Brazil | - |
dc.description.affiliation | [Moreno, R. A.; Abib, E., Jr.] Synchrophar Assessoria & Desenvolvimento Projetos, Campinas, SP, Brazil | - |
dc.description.affiliation | [Baglie, S.] Univ Estadual Ponta Grossa, Dept Pharmaceut Sci, Ponta Grossa, PR, Brazil | - |
dc.subject.wosarea | Pharmacology & Pharmacy | en |
dc.subject.researcharea | Pharmacology & Pharmacy | en |
Appears in Collections: | Artigos de Periódicos |
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