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http://repositorio.unitau.br/jspui/handle/20.500.11874/1781
metadata.dc.type: | Artigo de Periódico |
Title: | Effect of nitric oxide inhibitor and donor substances on the infammatory process caused by endodontic irrigants |
Authors: | Brito, Luciana Malheiro de Carreira, Cláudia de Moura Raldi, Denise Pontes Lage-Marques, José Luiz Habitante, Sandra Márcia Saad, Wilson Abraão |
Abstract: | Nitric oxide (NO) has been considered a key molecule in infammation. OBJECTIVE: The aim of this study was to evaluate the effect of treatment with L-NAME and sodium nitroprussiate, substances that inhibit and release NO, respectively, on tissue tolerance to endodontic irrigants. MATERIAL AND METHODS: The vital dye exudation method was used in a rat subcutaneous tissue model. Injections of 2% Evans blue were administered intravenously into the dorsal penial vein of 14 male rats (200-300 g). The NO inhibitor and donor substances were injected into the subcutaneous tissue in the dorsal region, forming two groups of animals: G1 was inoculated with L-NAME and G2 with sodium nitroprussiate. Both groups received injections of the test endodontic irrigants: acetic acid, 15% citric acid, 17% EDTA-T and saline (control). After 30 min, analysis of the extravasated dye was performed by light absorption spectrophotometry (620 nm). RESULTS: There was statistically signifcant difference (p<0.05) between groups 1 and 2 for all irrigants. L-NAME produced a less intense infammatory reaction and nitroprussiate intensifed this process. CONCLUSIONS: Independently of the administration of NO inhibitors and donors, EDTA-T produced the highest irritating potential in vital tissue among the tested irrigating solutions. |
metadata.dc.language: | Inglês |
metadata.dc.publisher.country: | Brasil |
Publisher: | Faculdade De Odontologia De Bauru - USP |
metadata.dc.rights: | Acesso Aberto |
metadata.dc.rights.uri: | https://creativecommons.org/licenses/by-nc-nd/4.0 |
metadata.dc.identifier.doi: | 10.1590/S1678-77572011000200006 |
URI: | http://repositorio.unitau.br/jspui/handle/20.500.11874/1781 |
Issue Date: | 2011 |
Appears in Collections: | Artigos de Periódicos |
Files in This Item:
File | Size | Format | |
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SCIELO S1678-77572011000200006.pdf | 63.97 kB | Adobe PDF | View/Open |
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