Please use this identifier to cite or link to this item: http://repositorio.unitau.br/jspui/handle/20.500.11874/2522
metadata.dc.type: Artigo de Periódico
Title: New diagnostic criteria for neurocysticercosis: Reliability and validity
Authors: Carpio, Arturo
Fleury, Agnes
Romo, Matthew L.
Abraham, Ronaldo
Fandino, Jaime
Duran, Juan C.
Cardenas, Graciela
Moncayo, Jorge
Rodrigues, Cleonisio Leite
San-Juan, Daniel
Serrano-Duenas, Marcos
Takayanagui, Oswaldo
Sander, Josemir W.
Abstract: ObjectiveThe diagnosis of neurocysticercosis (NCC) remains problematic because of the heterogeneity of its clinical, immunological, and imaging characteristics. Our aim was to develop and assess a new set of diagnostic criteria for NCC, which might allow for the accurate detection of, and differentiation between, parenchymal and extraparenchymal disease. MethodsA group of Latin American NCC experts developed by consensus a new set of diagnostic criteria for NCC. A multicenter, retrospective study was then conducted to validate it. The reference standard for diagnosis of active NCC was the disappearance or reduction of cysts after anthelmintic treatment. In total, three pairs of independent neurologists blinded to the diagnosis evaluated 93 cases (with NCC) and 93 controls (without NCC) using the new diagnostic criteria. Mixed-effects logistic regression models were used to estimate sensitivity and specificity. ResultsInter-rater reliability (kappa) of diagnosis among evaluators was 0.60. For diagnosis of NCC versus no NCC, the new criteria had a sensitivity of 93.2% and specificity of 81.4%. For parenchymal NCC, the new criteria had a sensitivity of 89.8% and specificity of 80.7% and for extraparenchymal NCC, the new criteria had a sensitivity of 65.9% and specificity of 94.9%. InterpretationThese criteria have acceptable reliability and validity and could be a new tool for clinicians and researchers. An advantage of the new criteria is that they consider parasite location (ie, parenchymal or extraparenchymal), which is an important factor determining the clinical, immunological, and radiological presentation of the disease, and importantly, its treatment and prognosis. Ann Neurol 2016;80:434-442
metadata.dc.language: Inglês
metadata.dc.publisher.country: Estados Unidos
Publisher: Wiley-Blackwell
metadata.dc.rights: Em verificação
metadata.dc.identifier.doi: 10.1002/ana.24732
URI: http://repositorio.unitau.br/jspui/handle/20.500.11874/2522
Issue Date: 2016
Appears in Collections:Artigos de Periódicos

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