Please use this identifier to cite or link to this item: http://repositorio.unitau.br/jspui/handle/20.500.11874/2978
metadata.dc.type: Artigo de Periódico
Title: Fluoxetine Inhibits Inflammatory Response and Bone Loss in a Rat Model of Ligature-Induced Periodontitis
Authors: Branco-de-Almeida, Luciana Salles
Franco, Gilson Cesar Nobre
Castro, Myrella Lessio
Santos, Juliana G. dos
Anbinder, Ana Lia
Cortelli, Sheila Cavalca
Kajiya, Mikihito
Kawai, Toshihisa
Rosalen, Pedro Luiz
Abstract: Background: Fluoxetine, a selective serotonin reuptake inhibitor, has been found recently to possess anti-inflammatory properties. The present study investigates the effects of fluoxetine on inflammatory tissue destruction in a rat model of ligature-induced periodontal disease. Methods: Thirty male Wistar rats were randomly assigned into three groups (n = 10 animals per group): 1) control rats (without ligature); 2) rats with ligature + placebo (saline; oral gavage); and 3) rats with ligature + fluoxetine (20 mg/kg/day in saline; oral gavage). Histologic analyses were performed on the furcation region and mesial aspect of mandibular first molars of rats sacrificed at 15 days after ligature-induced periodontal disease. Reverse transcription-polymerase chain reaction and zymography were performed to analyze the mRNA expression of interleukin (IL)-1 beta, cyclooxygenase (COX)-2, matrix metalloproteinase (MMP)-9 and inducible nitric oxide synthase and the MMP-9 activity, respectively, in gingival tissues samples. Results: Compared to the ligature + placebo group, alveolar bone loss was reduced in the fluoxetine group (P <0.05), and the amount of collagen fibers in the gingival tissue was maintained. Moreover, in gingival tissue sampled 3 days after ligature attachment, fluoxetine administration reduced IL-1 beta and COX-2 mRNA expression. Fluoxetine downregulated MMP-9 activity, without affecting MMP-9 mRNA expression induced by ligature, compared to the ligature + placebo group (P <0.05). These data suggest that fluoxetine suppressed proinflammatory responses, as well as proteolytic enzyme activity, induced by ligature. Conclusion: In the present study, fluoxetine suppresses the inflammatory response and protects against periodontal bone resorption and destruction of collagen fibers, suggesting that fluoxetine can constitute a promising therapeutic approach for periodontal diseases. J Periodontol 2012;83:664-671.
metadata.dc.language: Inglês
metadata.dc.publisher.country: Estados Unidos
Publisher: Amer Acad Periodontology
metadata.dc.rights: Em verificação
metadata.dc.identifier.doi: 10.1902/jop.2011.110370
URI: http://repositorio.unitau.br/jspui/handle/20.500.11874/2978
Issue Date: 2012
Appears in Collections:Artigos de Periódicos

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